1604833-41-1

Basic information

• Product Name: (R)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-1-(4-fluorophenyl)ethanone
• Synonyms: (R)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-1-(4-fluorophenyl)ethanone
• CAS NO: 1604833-41-1
• Molecular Weight: 321.329
• Mol File: 1604833-41-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-1-(4-fluorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-1-(4-fluorophenyl)ethanone(1604833-41-1)
• EPA Substance Registry System: (R)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-1-(4-fluorophenyl)ethanone(1604833-41-1)

Safety Data

• Hazardous Substances Data: 1604833-41-1(Hazardous Substances Data)

Upstream product

• 71730-46-6 benzo[e][1,2,3]oxathiazine 2,2-dioxide 
• 80646-00-0 3-(4-fluorophenyl)-3-oxopropanoic acid 

Relevant articles and documents

Substrate-Induced Dimerization Assembly of Chiral Macrocycle Catalysts toward Cooperative Asymmetric Catalysis

An artificial system of substrate-induced dimerization assembly of chiral macrocycle catalysts enables a highly cooperative hydrogen-bonding activation network for efficient enantioselective transformation. These macrocycles contain two thiourea and two chiral diamine moieties and dimerize with sulfate to form a sandwich-like assembly. The macrocycles then adopt an extended conformation and reciprocally complement the hydrogen-bonding interaction sites. Inspired by the guest-induced dynamic assembly, these macrocycles catalyze the decarboxylative Mannich reaction of cyclic aldimines containing a sulfamate heading group. The imine substrate can be activated toward nucleophilic attack of β-ketoacid by a cooperative hydrogen-bonding network enabled by sulfamate-induced dimerization assembly of the macrocycle catalysts. Highly efficient (>95 % yield in most cases) and enantioselective (up to 97.5:2.5 er) transformation of a variety of substrates using only 5 mol % macrocycle was achieved.