16064-04-3Relevant articles and documents
First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
Chosson, Elizabeth,Rochais, Christophe,Legay, Remi,Santos, Jana Sopkova De Oliveira,Rault, Sylvain,Dallemagne, Patrick
, p. 2548 - 2554 (2011)
Hitherto unknown fluorene-9-malonic acid and some substituted derivatives were easily synthesized in very mild conditions through the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids issued from the corresponding biphenylcarboxaldehydes.
A Photochemical Intramolecular C-N Coupling Toward the Synthesis of Benzimidazole-Fused Phenanthridines
Bera, Shyamal Kanti,Boruah, Palash J.,Parida, Shraddha Saraswati,Paul, Amit K.,Mal, Prasenjit
, p. 9587 - 9602 (2021)
Herein, we report a direct photochemical dehydrogenative C-N coupling of unactivated C(sp2)-H and N(sp2)-H bonds. The catalysts or additive-free transformation of 2-([1,1′-biphenyl]-2-yl)-1H-benzo[d]imidazole to benzo[4,5]imidazo[1,2-f]phenanthridine was achieved at ~350 nm of irradiation via ?-hydrogen abstraction. DFT calculations helped to understand that the N-H···πinteraction was essential for the reaction to proceed at a lower energy than expected.
K2S2O8-promoted radical trifluoromethylthiolation/spirocyclization for the synthesis of SCF3?featured spiro[5,5]trienones
Dai, Peng,Li, Bing,Shen, Liu-Yu,Sun, Yu,Wang, Yu-Qi,Yang, Wen-Chao
supporting information, (2022/01/24)
A direct and efficient strategy for the trifluoromethylthiolation and dearomatization of biaryl ynones with stable and readily available AgSCF3 has been developed. The reaction occurs smoothly in the presence of K2S2O8 via a 6-exo-trig radical cyclization, providing a variety of SCF3-containing spiro [5,5]trienones in good yields.
Chromium-Catalyzed Selective Cross-Electrophile Coupling between Unactivated C(aryl)-F and C(aryl)-O Bonds
Fan, Fei,Zhao, Lixing,Luo, Meiming,Zeng, Xiaoming
supporting information, p. 561 - 568 (2022/03/15)
Chemically inert C(aryl)-F bonds have rarely been used to couple with other unactivated bonds, and this remains a challenge because of the difficulty of the successive cleavage of two unactivated bonds by metal catalysis. We report here the chromium-catalyzed cleavage of chemically inert C(aryl)-F bonds for coupling with unactivated C(aryl)-O bonds, allowing cross-electrophile coupling between unreactive aryl fluorides and aryl esters to be achieved in high regio- and chemoselectivity. The reactive Cr, which was formed in situ by reducing CrCl2, enables cleavage of the o-C(aryl)-F bonds to afford monovalent and quartet cyclochromate; subsequent bipyridyl-enabled insertion into the ester C(aryl)-O bond followed by reductive elimination allowed the orthogonal coupling of these two different and unactivated bonds. Mechanistic studies indicate that the bipyridyl ligand greatly enhances the reactivity of Cr in the cleavage of C(aryl)-O bonds, and the second oxidative addition may occur sluggishly compared with the reductive elimination in the catalytic cycle.
“TPG-lite”: A new, simplified “designer” surfactant for general use in synthesis under micellar catalysis conditions in recyclable water
Thakore, Ruchita R.,Takale, Balaram S.,Hu, Yuting,Ramer, Selene,Kostal, Jakub,Gallou, Fabrice,Lipshutz, Bruce H.
, (2021/04/22)
Using the oxidized, carboxylic acid-containing form of MPEG-750, esterification with racemic vitamin E affords a new surfactant (TPG-lite) that functions as an enabling, nanoreactor-forming amphiphile for use in many types of important reactions in synthesis. The presence of a single ester bond is suggestive of simplified treatment as a component of (eventual) reaction waste water, after recycling. Many types of reactions, including aminations, Suzuki-Miyaura, SNAr, and several others are compared directly with TPGS-750-M, leading to the conclusion that TPG-lite can function as an equivalent nanomicelle-forming surfactant in water. Prima facie evidence amassed via DLS and cryo-TEM analyses support these experimental observations. In silico evaluations of the aquatic toxicity and carcinogenicity of TPG-lite indicate that it is safe to use.