160709-02-4 Usage
Description
D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)is a complex organic compound with a unique chemical structure. It is characterized by its pentitol backbone, which is modified with various functional groups, including a 2,4-difluorophenyl group, a hydroxymethyl group, and a 1,2,4-triazol-1-yl group. D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)is known for its potential applications in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)is used as a building block for the synthesis of key intermediates towards the synthesis of highly active azole antifungals, such as Sch 51048, Sch 56592, and Sch 45012. These antifungal agents are effective against a wide range of fungal infections and are crucial in the treatment of various medical conditions.
Additionally, D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxymethyl)-1-(1H-1,2,4-triazol-1-yl)is also an impurity/intermediate for posaconazole (P689600), which is a potent antifungal drug used to treat severe fungal infections, particularly in immunocompromised patients. The compound plays a significant role in the development and production of these life-saving medications, contributing to the advancement of medical treatments for fungal infections.
Check Digit Verification of cas no
The CAS Registry Mumber 160709-02-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,0,7,0 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 160709-02:
(8*1)+(7*6)+(6*0)+(5*7)+(4*0)+(3*9)+(2*0)+(1*2)=114
114 % 10 = 4
So 160709-02-4 is a valid CAS Registry Number.
160709-02-4Relevant articles and documents
A PROCESS FOR THE MANUFACTURE OF POSACONAZOLE
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Page/Page column 9; 28; 29, (2019/05/10)
The present invention discloses an improved process for the manufacture of Posaconazole, an anti-fungal agent belonging to the category of substituted Tetrahydrofuran Triazole compound. The present invention further describes preparation of formula A and formula B, the key intermediates in the preparation of Posaconazole. The invention also discloses novel intermediates that are useful in the synthesis of Posaconazole.
Purification of Posaconazole Intermediates
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Paragraph 0157 - 0161, (2014/10/28)
The present invention relates to a process for the purification of chiral compounds, in particular to the purification of a chiral compound of formula (XI) which may be used as intermediate for the preparation of antifungal agents, preferably posaconazole.
PREPARATION OF POSACONAZOLE INTERMEDIATES
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, (2011/12/04)
The present invention relates to process for the preparation of a chiral compound of formula (IX) or a salt thereof, wherein Y1and Y2 are independently F or C1, preferably F, the crystalline compound of formula (IX) as such, and its use for the preparation of an antifungal agent.