16078-63-0

Basic information

• Product Name: ethyl 3-aMino-1-phenyl-1H-pyrazole-4-carboxylate
• Synonyms: ethyl 3-aMino-1-phenyl-1H-pyrazole-4-carboxylate;3-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS NO: 16078-63-0
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.25052
• Mol File: 16078-63-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 385.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.26±0.10(Predicted)
• CAS DataBase Reference: ethyl 3-aMino-1-phenyl-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-aMino-1-phenyl-1H-pyrazole-4-carboxylate(16078-63-0)
• EPA Substance Registry System: ethyl 3-aMino-1-phenyl-1H-pyrazole-4-carboxylate(16078-63-0)

Safety Data

• Hazardous Substances Data: 16078-63-0(Hazardous Substances Data)

Usage

General Description

Ethyl 3-amino-1-phenyl-1H-pyrazole-4-carboxylate is a chemical compound with the molecular formula C13H13N3O2. It is a pyrazole derivative, which means it contains a five-membered heterocyclic ring with two nitrogen atoms. ethyl 3-aMino-1-phenyl-1H-pyrazole-4-carboxylate has a phenyl group attached to the pyrazole ring, and an ethyl ester group attached to the carboxylate functional group. It has potential applications in the field of medicinal chemistry, as pyrazole derivatives have been studied for their various pharmacological activities, including anti-inflammatory, antiviral, and anticancer properties. Overall, ethyl 3-amino-1-phenyl-1H-pyrazole-4-carboxylate is a compound with interesting structural and pharmacological properties that warrant further study and exploration.

Upstream product

• 588-64-7 benzaldehyde phenylhydrazone 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 591-50-4 iodobenzene 
• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 
• 100-63-0 phenylhydrazine 

Downstream Products

• 132680-70-7 1-phenyl-3-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 122800-03-7 3-(4-Fluoro-2-nitro-phenylamino)-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1003578-23-1 ethyl 3-(bis(tert-butoxycarbonyl)amino)-1-phenyl-1H-pyrazole-4-carboxylate 
• 122799-81-9 7-Fluoro-10-(4-methyl-piperazin-1-yl)-2-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene 
• 132680-66-1 2-phenyl-2H,4H-pyrazolo<4,3-b>pyrrolizine 
• 132680-72-9 4-oxo-2-phenyl-2H,4H-pyrazolo<4,3-b>pyrrolizine 
• 132680-71-8 1-phenyl-3-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxylic acid 
• 132680-27-4 1-phenyl-3-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxylic acid pyrrolidinamide 
• 865868-84-4 ethyl 1-phenyl-3-(phenylamino)-1H-pyrazole-4-carboxylate 
• 865868-13-9 ethyl 3-[(1-methylethyl)amino]-1-phenyl-1H-pyrazole-4-carboxylate 
• 865868-86-6 ethyl 3-{[(trans-4-methylcyclohexyl)carbonyl]amino}-1-phenyl-1H-pyrazole-4-carboxylate 
• 865868-99-1 ethyl 1-phenyl-3-[(2-pyrazinylmethyl)amino]-1H-pyrazole-4-carboxylate 
• 865868-88-8 1,1-dimethylethyl 4-({4-[(ethyloxy)carbonyl]-1-phenyl-1H-pyrazol-3-yl}amino)-1-piperidinecarboxylate 
• 923010-31-5 3-amino-1-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

HETERO-HALO INHIBITORS OF HISTONE DEACETYLASE

This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.

Application of Ullmann and Ullmann-Finkelstein reactions for the synthesis of N-aryl-N-(1H-pyrazol-3-yl) acetamide or N-(1-aryl-1H-pyrazol-3-yl) acetamide derivatives and pharmacological evaluation

Ullmann-type reactions are becoming a major tool in medicinal chemistry. In this article, we describe the use of these Copper-catalyzed reactions with various precursors, acyl-heteroarylamines or pyrazoles of interest for pharmacomodulation. To the medicinal chemist they offer new, usually untapped disconnection approaches to compounds of interest. They thus open the way to new original analogues of bioactive compounds possibly not patented, from common building-blocks. They also allow C to N bioisosteric replacements, which sometimes are synthetically challenging. We report for the first time the critical effect of acetylamino substituents on the regioselective arylation of unsymmetrical pyrazoles that are useful for medicinal chemists. Finally, we have applied this strategy to the design of novel AT1 receptor antagonists. Though this family has been extensively investigated in the past 30 years, N-arylation and C to N replacement made possible by Ullmann chemistry, can produce original antagonists.

Heterocyclic system. XI. Synthesis of 1H,4H-pyrazolo[4,3-b]pyrrolizine and 2H,4H-pyrazolo[4,3-b]pyrrolizine derivatives

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