16081-87-1

Basic information

• Product Name: Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-
• CAS NO: 16081-87-1
• Molecular Formula: C13H9N3O
• Molecular Weight: 223.234
• Mol File: 16081-87-1.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-(16081-87-1)
• EPA Substance Registry System: Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-(16081-87-1)

Safety Data

• Hazardous Substances Data: 16081-87-1(Hazardous Substances Data)

Usage

General Description

Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl- is a chemical compound with a pyrimidine ring fused with a pyridine ring and a phenyl group attached to the second position of the pyrimidine ring. It is commonly used as a building block in organic synthesis and pharmaceutical research. Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl- has been studied for its potential biological activities, including as an antitumor agent, an inhibitor of protein kinases, and a potential treatment for cardiovascular diseases. Its structure and properties make it a versatile and important chemical in the field of medicinal chemistry and drug development.

Upstream product

• 13438-65-8 2-aminopyridine-3-carboxamide 
• 100-53-8 phenylmethanethiol 
• 100-46-9 benzylamine 
• 108-88-3 toluene 
• 1663-61-2 triethoxymethylbenzene 
• 98-88-4 benzoyl chloride 
• 14667-47-1 methyl 2-aminonicotinate 
• 144267-78-7 methyl 2-(N-benzoylamino)-nicotinate 
• 100-51-6 benzyl alcohol 
• 87674-18-8 2-bromonicotinamide 
• 100-52-7 benzaldehyde 
• 35905-85-2 2-bromonicotinic acid 
• 618-39-3 benzamidin 
• 40134-18-7 methyl 2-chloropyridine-3-carboxylate 

Downstream Products

• 353278-21-4 2-phenyl-N-(3-(trifluoromethyl)phenyl)pyrido[2,3-d]pyrimidin-4-amine 
• 41803-67-2 4-chloro-2-phenylpyrido[2,3-d]pyrimidine 
• 1436866-40-8 ethyl 2-[4-[(2-phenylpyrido[2,3-d]pyrimidin-4-yl)amino]phenyl]acetate 
• 1436866-41-9 2-[4-[(2-phenylpyrido[2,3-d]pyrimidin-4-yl)amino]phenyl]acetic acid 
• 1436866-39-5 (2-phenylpyrido[2,3-d]pyrimidin-4-yl) trifluoromethanesulfonate 

Relevant articles and documents

An efficient transition-metal-free route to quinazolin-4(3H)-onesvia2-aminobenzamides and thiols

An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction ofo-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step.

Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp3 carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95percent. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles. This journal is

New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold

Multidrug resistance (MDR) occurring during cancer chemotherapy is a major obstacle for effectiveness and response to therapy and is often caused by ATP-binding cassette (ABC) efflux transporters. Belonging to the family of ABC transporters, breast cancer