1608464-07-8Relevant articles and documents
Biological evaluation of new mimetics of annonaceous acetogenins: Alteration of right scaffold by click linkage with aromatic functionalities
Liu, Yanghan,Xiao, Qicai,Liu, Yongqiang,Li, Zheng,Qiu, Yatao,Zhou, Guang-Biao,Yao, Zhu-Jun,Jiang, Sheng
, p. 248 - 258 (2014/04/17)
A small library of analogues of annonaceous acetogenins through click linkage with aromatic moieties is established using a convergent modular fragment-assembly approach. These analogues exhibited low micromolar inhibitory activities against the proliferation of several human cancer cell lines. Structure-activity relationship (SAR) of these analogues indicates that replacement of the methoxy groups of ubiquinone ring with methyl groups is proved to be a useful strategy for improving the anticancer activity of quinone-acetogenin hybrids.