1608503-36-1

Basic information

• Product Name: C₂₅H₂₁ClF₂N₆O
• CAS NO: 1608503-36-1
• Molecular Weight: 494.931
• Mol File: 1608503-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₁ClF₂N₆O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₁ClF₂N₆O(1608503-36-1)
• EPA Substance Registry System: C₂₅H₂₁ClF₂N₆O(1608503-36-1)

Safety Data

• Hazardous Substances Data: 1608503-36-1(Hazardous Substances Data)

Upstream product

• 91476-82-3 tetrahydro-5,6,7,8 imidazo<1,2-a>pyrazinecarboxylate-2 d'ethyle 
• 1053656-22-6 7-(tert-butyl) 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate 
• 77112-52-8 ethyl imidazo[1,2-a]pyrazine-2-carboxylate 
• 1373615-78-1 2',5'-dichloro-3,5-dimethyl-2,4'-bipyridine 
• 847664-64-6 (2,5-dichloropyridin-4-yl)boronic acid 
• 92992-85-3 2-bromine-3,5-dimethylpyridine 
• 1608503-20-3 7-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid 
• 3863-11-4 3,4-difluoroaniline 
• 1608503-19-0 ethyl 7-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate 

Relevant articles and documents

Scaffold hopping approach to a new series of smoothened antagonists

The hedgehog (Hh) signaling pathway is a key regulator during embryonic development, while in adults, it has limited functions such as stem cell maintenance and tissue repair. The aberrant activity of the Hh signaling in adults has been linked to numerous human cancers. Inhibition of Hh signaling therefore represents a promising approach toward novel anticancer therapies. The Smoothened (Smo) receptor mediates Hh signaling. Here we report a new series of Smo antagonists which were obtained by a scaffold hopping strategy. Compounds from this new scaffold demonstrated decent inhibition of Hh pathway signaling. The new scaffold can serve as a starting point for further optimization.