1608504-78-4

Basic information

• Product Name: (1S,2S)-1-((E)-(3,5-ditert-butyl-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol
• Synonyms: (1S,2S)-1-((E)-(3,5-ditert-butyl-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol
• CAS NO: 1608504-78-4
• Molecular Weight: 365.516
• Mol File: 1608504-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2S)-1-((E)-(3,5-ditert-butyl-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-1-((E)-(3,5-ditert-butyl-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol(1608504-78-4)
• EPA Substance Registry System: (1S,2S)-1-((E)-(3,5-ditert-butyl-2-hydroxybenzylidene)amino)-2,3-dihydro-1H-inden-2-ol(1608504-78-4)

Safety Data

• Hazardous Substances Data: 1608504-78-4(Hazardous Substances Data)

Upstream product

• 37942-07-7 3,5-di-tert-butyl-2-hydroxybenzaldehyde 
• 163061-74-3 (1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol 

Relevant articles and documents

Screening of a library of hemisalen ligands in asymmetric H-transfer: Reduction of aromatic ketones in water

A library of chiral hemisalen ligands (30) was realized. The ligands were synthesized by the condensation of salicylaldehyde derivatives with amino-alcohols (amino-indanol or substituted amino-ethanol) and characterized. These ligands associated with ruthenium (II) precursors were tested on the asymmetric transfer hydrogenation (ATH) of aromatic ketones by sodium formate in water. The different substituent pattern on the ligand (electronic and hindrance effects on different positions) as well as the ruthenium precursor were investigated. The best compromise in terms of conversion and chiral induction led to the complex [RuCl2(mesitylene)]2 coordinated to (1S,2R)-1-((E)-(3-(dimethyl(phenyl)silyl)-2-hydroxy-5-methoxy benzylidene) amino)-2,3-dihydro-1H-inden-2-ol (L25). It reduces acetophenone in 95% yield and 91% ee in 18 h at 30°C.