1609388-83-1

Basic information

• Product Name: N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• Synonyms: N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• CAS NO: 1609388-83-1
• Molecular Weight: 471.463
• Mol File: 1609388-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide(1609388-83-1)
• EPA Substance Registry System: N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide(1609388-83-1)

Safety Data

• Hazardous Substances Data: 1609388-83-1(Hazardous Substances Data)

Upstream product

• 312635-16-8 5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 312635-19-1 ethyl 5-phenyl-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 120-92-3 cyclopentanone 
• 848422-70-8 C₁₄H₇ClF₃N₃O 
• 77651-38-8 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide 

Relevant articles and documents

Optimization of small-molecule inhibitors of influenza virus polymerase: From thiophene-3-carboxamide to polyamido scaffolds

Influenza virus infections represent a serious concern to public health, being characterized by high morbidity and significant mortality. To date, compounds targeting the viral ion-channel M2 or the viral neuraminidase are the drugs available for treatment of influenza, but the emergence of drug-resistant viral mutants renders the search for novel targets and their possible inhibitors a major priority. Recently, we demonstrated that the viral RNA-dependent RNA polymerase (RdRP) complex can be an optimal target of protein-protein disruption by small molecules, with thiophene-3-carboxamide derivatives emerging as promising candidates for the development of new anti-influenza drugs with broad-spectrum activity. Here, we report a further dissection of the thiophene-3-carboxamide structure. By using a GRID molecular interaction field (MIF)-based scaffold-hopping approach, more potent and nontoxic polyamido derivatives were identified, highlighting a new space in the chemical variability of RdRP inhibitors. Finally, a possible pharmacophoric model highlighting the key features required for RdRP inhibition is proposed.