160948-35-6

Basic information

• Product Name: 2-amino-4-chloro-5-nitropyrimidine
• Synonyms: 2-amino-4-chloro-5-nitropyrimidine;4-Chloro-5-nitropyriMidin-2-aMine
• CAS NO: 160948-35-6
• Molecular Formula: C₄H₃ClN₄O₂
• Molecular Weight: 174.54522
• Mol File: 160948-35-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 430.2±48.0 °C(Predicted)
• Appearance: /
• Density: 1.712±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: -0.17±0.10(Predicted)
• CAS DataBase Reference: 2-amino-4-chloro-5-nitropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-chloro-5-nitropyrimidine(160948-35-6)
• EPA Substance Registry System: 2-amino-4-chloro-5-nitropyrimidine(160948-35-6)

Safety Data

• Hazardous Substances Data: 160948-35-6(Hazardous Substances Data)

Usage

General Description

2-amino-4-chloro-5-nitropyrimidine, also known as 4-Chloro-5-nitro-2-aminopyrimidine, is a chemical compound with the molecular formula C4H3ClN4O2. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-amino-4-chloro-5-nitropyrimidine is classified as a pyrimidine derivative, containing a pyrimidine ring with an amino group at position 2, a chlorine atom at position 4, and a nitro group at position 5. It is known for its versatility in organic synthesis and is often used as a building block for the construction of more complex compounds. 2-amino-4-chloro-5-nitropyrimidine is a valuable chemical in the pharmaceutical and agricultural industries, contributing to the development of various important products.

Upstream product

• 49845-33-2 2,4-Dichloro-5-nitropyrimidine 
• 7254-29-7 2-amino-4-hydroxy-5-nitropyrimidine 
• 7254-29-7 2-amino-5-nitropyrimidin-4(3H)-one 

Downstream Products

• 18620-73-0 2,4-diamino-5-nitropyrimidine 
• 1394119-43-7 4-(6-iodo-1H-indazol-1-yl)-5-nitropyrimidin-2-amine 

Relevant articles and documents

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines

The present invention provides 8-substituted O6 -benzylguanines of the formula STR1 wherein R1, R2, and R3 are as defined in the specification, and 4(6)-substituted 2-amino-5-nitro-6(4)-benzyloxypyrimidine, and 4(6)-substituted 2-amino-5-nitroso-6(4)-benzyloxypyrimidine derivatives which have been found to be effective AGT inactivators, as well as pharmaceutical compositions comprising such derivatives along with a pharmaceutically acceptable carrier. The present invention further provides a method of enhancing the chemotherapeutic treatment of tumor cells in a mammal with an antineoplastic alkylating agent which causes cytotoxic lesions at the O6 -position of guanine, by administering to a mammal an effective amount of one of the aforesaid derivatives, 2,4-diamino-6-benzyloxy-s-triazine, 5-substituted 2,4-diamino-6-benzyloxypyrimidines, or 8-aza-O6 -benzylguanine, and administering to the mammal an effective amount of an antineoplastic alkylating agent which causes cytotoxic lesions at the O6 -position of guanine.

Structure-Activity Relations. Part 12. Antibacterial Activity of a Series of 2,4-Diamino-6-substituted 5-(4-pyridylmethylamino)pyrimidines and 2,4-Diamino-5-(4-substituted benzylamino)pyrimidines.

A series of 6-substituted 2,4-diamino-5-(4-pyridylamino)pyrimidines and of 2,4-diamino-5-(4-substituted benzylamino)pyrimidines has been prepared.Their antibacterial activity towards L. casei, S. aureus and E. coli has been investigated.These activities have been successfully correlated by Hansch-type relations.Dependence on both lipophilicity and electronic (polar) factors has been found.The results are related to the structure and interactions with the receptor.