16095-32-2Relevant articles and documents
Pd-Catalyzed Intramolecular Chemoselective C(sp2)-H and C(sp3)-H Activation of N-Alkyl- N-arylanthranilic Acids
Hu, Zhe-Yao,Zhang, Yan,Li, Xin-Chang,Zi, Jing,Guo, Xun-Xiang
, p. 989 - 992 (2019/05/16)
A controllable palladium-catalyzed intramolecular C-H activation of N-alkyl-N-arylanthranilic acids has been developed. The methodology allows selective synthesis of 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones and carbazoles from the same starting materials and palladium catalyst. The selectivity is controlled by the oxidant. Silver oxide promotes C(sp3)-H activation/C-O cyclization to provide 1,2-dihydro-(4H)-3,1-benzoxazin-4-ones, while copper acetate contributes to C(sp2)-H activation/decarboxylative arylation to afford carbazoles. This protocol is demonstrated by its wide substrate scope and good functional group tolerance.
Organocatalytic enantioselective amination of 2-substituted indolin-3-ones: A strategy for the synthesis of chiral α-hydrazino esters
Yarlagadda, Suresh,Ramesh,Ravikumar Reddy,Srinivas,Sridhar,Subba Reddy
supporting information, p. 170 - 173 (2017/11/27)
An efficient enantioselective α-amination of 2-substituted 3-indolinones has been achieved for the first time using hydroquinidine as a chiral catalyst through an aza-Michael reaction. The desired α-hydrazino esters are obtained in excellent yields with h
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6- fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5-trimethyl-4- thiazolidinone maleate
Hrib, Nicholas J.,Jurcak, John G.,Bregna, Deborah E.,Burgher, Kendra L.,Hartman, Harold B.,Kafka, Sharon,Kerman, Lisa L.,Kongsamut, Sam,Roehr, Joachim E.,Szewczak, Mark R.,Woods-Kettelberger, Ann T.,Corbett, Roy
, p. 4044 - 4057 (2007/10/03)
HP-236 (3-[4-[4-(6-Fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone maleate; P-9236) (54) displayed a pharmacological profile indicative of potential atypical antipsychotic activity. A series of piperazinyl butyl thiazolidi