1609583-99-4

Basic information

• Product Name: 2-((Z)-2-(2-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate
• Synonyms: 2-((Z)-2-(2-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate
• CAS NO: 1609583-99-4
• Molecular Weight: 455.854
• Mol File: 1609583-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((Z)-2-(2-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((Z)-2-(2-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate(1609583-99-4)
• EPA Substance Registry System: 2-((Z)-2-(2-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 2,3-dihydro-1,4-benzodioxine-5-carboxylate(1609583-99-4)

Safety Data

• Hazardous Substances Data: 1609583-99-4(Hazardous Substances Data)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 1609584-70-4 C₁₅H₁₅N₃O₆ 
• 38871-41-9 2,3-dihydrobenzo-[b]-1,4-dioxine-5-carbonyl chloride 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 1609584-27-1 2-(2-((Z)-2-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethanol 
• 443-48-1 metronidazole 
• 2411-83-8 methyl-2,3-dihydroxybenzoate 
• 4442-53-9 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid 
• 1609584-52-2 2-(2-((Z)-2-chlorostyryl)-5-nitro-1H-imidazol-1-yl)ethyl 4-methylbenzenesulfonate 

Relevant articles and documents

Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety as FAK inhibitors with anticancer activity

A series of 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety (3a-3r) has been designed, synthesized and their biological activities were also evaluated as potential antiproliferation and focal adhesion kinase (FAK) inhibitors. Among all the compounds, 3p showed the most potent activity in vitro which inhibited the growth of A549 with IC 50 value of 3.11 μM and Hela with IC50 value of 2.54 μM respectively. Compound 3p also exhibited significant FAK inhibitory activity (IC50 = 0.45 μM). Docking simulation was performed for compound 3p into the FAK structure active site to determine the probable binding model.