16098-21-8

Basic information

• Product Name: 3-Bromo-1-methyl-5-nitro-1H-pyridin-2-one
• Synonyms: 3-Bromo-1-methyl-5-nitro-1H-pyridin-2-one;3-Bromo-1-methyl-5-nitropyridin-2(1H)-one
• CAS NO: 16098-21-8
• Molecular Formula: C₆H₅BrN₂O₃
• Molecular Weight: 233.0195
• EINECS: -0
• Mol File: 16098-21-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Bromo-1-methyl-5-nitro-1H-pyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-1-methyl-5-nitro-1H-pyridin-2-one(16098-21-8)
• EPA Substance Registry System: 3-Bromo-1-methyl-5-nitro-1H-pyridin-2-one(16098-21-8)

Safety Data

• Hazardous Substances Data: 16098-21-8(Hazardous Substances Data)

Upstream product

• 5470-17-7 3-bromo-2-chloro-5-nitropyridine 
• 77-78-1 dimethyl sulfate 
• 32896-90-5 1-methyl-5-nitro-2(1H)-pyridone 
• 506-68-3 bromocyane 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 5418-51-9 5-nitro-2-pyridone 

Downstream Products

• 868371-72-6 3-(2,4-dimethylphenyl)-1-methyl-5-nitropyridin-2(1H)-one 

Relevant articles and documents

Spiro derivative, preparation method thereof and application of spiro derivative in medicine

The invention relates to a spiro derivative, a preparation method thereof and application of the spiro derivative in medicine. Specifically, the invention relates to the spiro derivative shown in a general formula (I), the preparation method thereof, a pharmaceutical composition containing the spiro derivative and application of the spiro derivative as a therapeutic agent, especially application of the spiro derivative as an RAF inhibitor and application of the spiro derivative in preparation of drugs for treating or preventing various diseases (including cancers) related to over-expression RAF activity.

CYCLIC COMPOUNDS

There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring Ab is a 5-or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, -O-, -S-, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; … is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, -O-, -S-, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.