16098-80-9

Basic information

• Product Name: Benzeneacetic acid, a-cyclopentyl-a-hydroxy-, ethyl ester
• CAS NO: 16098-80-9
• Molecular Formula: C15H20O3
• Molecular Weight: 248.322
• Mol File: 16098-80-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-cyclopentyl-a-hydroxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-cyclopentyl-a-hydroxy-, ethyl ester(16098-80-9)
• EPA Substance Registry System: Benzeneacetic acid, a-cyclopentyl-a-hydroxy-, ethyl ester(16098-80-9)

Safety Data

• Hazardous Substances Data: 16098-80-9(Hazardous Substances Data)

Upstream product

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 32916-51-1 cyclopentylmagnesium chloride 

Downstream Products

• 19276-76-7 Allyloxy-cyclopentyl-phenyl-acetic acid ethyl ester 
• 26758-53-2 3-quinuclidinyl α-hydroxy-α-cyclopentylphenylacetate 
• 427-49-6 2-cyclopentyl-2-hydroxy-2-phenylacetic acid 
• 19277-02-2 2-Allyloxy-2-cyclopentyl-2-phenyl-acetamide 
• 712356-14-4 (1α, 5α ,6α)-6-N-(3-azabicyclo[3.1.0] hexyl-3-benzyl)-2-cyclopentyl-2-hydroxy-2-phenyl acetamide 
• 712356-15-5 (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl-3-(4-methyl-3-pentenyl))-2-cyclopentyl-2-hydroxy-2-phenyl acetamide 
• 712356-39-3 (1α, 5α, 6α)-6-N-(3-azabicyclo-[3.1.0] hexyl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide 

Relevant articles and documents

Fluorine-containing 1,4-disubstituted piperidine derivatives

Novel fluorine-containing 1,4-disubstituted piperidine derivatives, represented by general formula ?I! STR1 such as, for example, (2R)-N-?1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl!-2-?(1R)-3,3-difluorocyclopentyl!-2-hydroxy-2-phenylacetamide or pharmaceutically acceptable salt thereof, are potent and selective antagonists for muscarinic M3 receptors with little side effects. The compounds of formula ?I! exhibit excellent oral activity, duration of activity and pharmacolkinetics. They are useful for treatment and prophylaxis of respiratory diseases, such as chronic obstructive pulmonary diseases; urinary diseases, such as urinary incontinence; and digestive diseases, such as irritable bowel syndrome, and motion sickness.

Analogues of 3-Quinuclidinyl Benzilate

A number of analogues of 3-quinuclidinyl benzilate (QNB) have been synthesized and their affinities to muscarinic receptor from rat or dog ventricular muscle measured.We have determined that the muscarinic receptor can to a different degree accomodate either a halogen in the ortho, meta, or para position of one phenyl ring or the repalcement of one phenyl ring with an alkyl group.Our in vitro competition studies show that the affinities lie within a 270-fold range, from the highest affinity compound, 3-quinuclidinyl α-hydroxy-α-cyclopentylphenylacetate (2), to the lowest affinity compound, 3-quinuclidinyl α-hydroxy-α-2-propargylphenylacetate (11).