1610346-16-1

Basic information

• Product Name: 4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-amine
• Synonyms: 4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-amine
• CAS NO: 1610346-16-1
• Molecular Weight: 265.318
• Mol File: 1610346-16-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-amine(1610346-16-1)
• EPA Substance Registry System: 4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-amine(1610346-16-1)

Safety Data

• Hazardous Substances Data: 1610346-16-1(Hazardous Substances Data)

Upstream product

• 7752-78-5 5-bromo-2-methylpyrimidine 
• 934397-98-5 5-amino-4-methyl-1-phenyl-1H-pyrazol-3(2H)-one 
• 100-63-0 phenylhydrazine 
• 1052686-67-5 2-methyl-5-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 
• 1414578-42-9 5-amino-4-methyl-1-phenyl-1H-pyrazol-3-yl trifluoromethane sulfonate 

Downstream Products

• 1610415-07-0 1-(2-cyclopropyl-5-(methoxymethyl)benzyl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-yl)urea 

Relevant articles and documents

PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES

The present invention relates to a class of TrkA inhibitors and an application thereof in the preparation of a drug for the treatment of diseases associated with TrkA. The present invention specifically discloses compounds represented by formula (I) and f

N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.