1610500-90-7

Basic information

• Product Name: ethyl 2,2-difluoro-2-(8-phenylphenanthridin-6-yl)acetate
• Synonyms: ethyl 2,2-difluoro-2-(8-phenylphenanthridin-6-yl)acetate
• CAS NO: 1610500-90-7
• Molecular Weight: 377.39
• Mol File: 1610500-90-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 2,2-difluoro-2-(8-phenylphenanthridin-6-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,2-difluoro-2-(8-phenylphenanthridin-6-yl)acetate(1610500-90-7)
• EPA Substance Registry System: ethyl 2,2-difluoro-2-(8-phenylphenanthridin-6-yl)acetate(1610500-90-7)

Safety Data

• Hazardous Substances Data: 1610500-90-7(Hazardous Substances Data)

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 76129-23-2 [1,1':4',1''-terphenyl]-2-amine 
• 1453098-09-3 2‐isocyano‐1,1':4',1''‐terphenyl 

Relevant articles and documents

Catalytic synthesis method of 6-difluorophenanthridine compound

The invention discloses a catalytic synthesis method of a 6-difluorophenanthridine compound. According to the catalytic synthesis method disclosed by the invention, an o-aminobiphenyl compound and ethyl bromodifluoroacetate are subjected to defluorination reaction under the participation of Cu(OTf)2, so as to obtain the 6-difluorophenanthridine compound. The reaction has good functional group compatibility; drugs used by the catalytic synthesis method provided by the invention can be directly purchased and the catalytic synthesis method is simple to operate and has high efficiency and safety;the reaction is simple and an application prospect of the reaction in industry is greatly improved.

Visible-light-mediated fluoroalkylation of isocyanides with ethyl bromofluoroacetates: Unified synthesis of mono- and difluoromethylated phenanthridine derivatives

A practical and unified strategy has been described for the preparation of mono- and difluoromethylated phenanthridine derivatives using a visible-light-promoted alkylation and decarboxylation sequence from biphenyl isocyanides with ethyl bromofluoroacetate (EBFA) or ethyl bromodifluoroacetate (EBDFA). These reactions could be carried out at room temperature in good to excellent chemical yields. Both stepwise and one-pot procedures have been developed, which makes this strategy more attractive.