1610681-17-8Relevant articles and documents
Establishment of a structure-activity relationship of 1 H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness
Seixas, Jo?o D.,Luengo-Arratta, Sandra A.,Diaz, Rosario,Saldivia, Manuel,Rojas-Barros, Domingo I.,Manzano, Pilar,Gonzalez, Silvia,Berlanga, Manuela,Smith, Terry K.,Navarro, Miguel,Pollastri, Michael P.
, p. 4834 - 4848 (2014/07/07)
Compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3- kinases and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against Trypanosoma brucei cultures. With an eye toward using 1 as a starting point for ant