1610702-02-7

Basic information

• Product Name: 2-bromo-1,3-bis(ethoxymethoxy)benzene
• Synonyms: 2-bromo-1,3-bis(ethoxymethoxy)benzene
• CAS NO: 1610702-02-7
• Molecular Weight: 305.169
• Mol File: 1610702-02-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-1,3-bis(ethoxymethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1,3-bis(ethoxymethoxy)benzene(1610702-02-7)
• EPA Substance Registry System: 2-bromo-1,3-bis(ethoxymethoxy)benzene(1610702-02-7)

Safety Data

• Hazardous Substances Data: 1610702-02-7(Hazardous Substances Data)

Upstream product

• 6751-75-3 2-bromoresorcinol 
• 3188-13-4 ethyl chloromethyl ether 

Downstream Products

• 1610702-06-1 (S)-3-(2,6-bis(ethoxymethoxy)phenyl)-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethylpropanamide 
• 1610702-08-3 C₂₆H₃₅NO₆ 
• 1610702-22-1 4-triisopropylsilyloxy-(4R,6S)-2-((S)-1-(2,6-bis-(ethoxymethoxy)phenyl)propan-2-yl)-2-methoxy-6-methyltetrahydro-2H-pyran 
• 1610702-16-3 (2S,5R,7S)-1-(2,6-bis(ethoxymethoxy)phenyl)-5-hydroxy-7-((4-methoxybenzyl)oxy)-2-methyloctan-3-one 
• 1610702-12-9 (S)-4-(2,6-bis(ethoxymethoxy)phenyl)-3-methylbutan-2-one 

Relevant articles and documents

Total synthesis of virgatolide b via exploitation of intramolecular hydrogen bonding

A full account of the enantioselective total synthesis of virgatolide B is reported. Key features of the synthesis include an sp3-sp2 Suzuki-Miyaura cross-coupling of a β-trifluoroboratoamide with an aryl bromide, regioselective intramolecular carboalkoxylation, and a 1,3-anti-selective Mukaiyama aldol reaction. Intramolecular hydrogen bonding governed the regioselectivity of the key spiroketalization step, affording the natural product as a single regioisomer.