1610791-81-5Relevant articles and documents
Developing efficient nucleophilic fluorination methods and application to substituted picolinate esters
Allen, Laura J.,Lee, Shin Hee,Cheng, Yang,Hanley, Patrick S.,Muhuhi, Joseck M.,Kane, Elisabeth,Powers, Stacey L.,Anderson, John E.,Bell, Bruce M.,Roth, Gary A.,Sanford, Melanie S.,Bland, Douglas C.
, p. 1045 - 1054 (2014)
This report describes nucleophilic fluorination of 3 and 5-substituted picolinate ester substrates using potassium fluoride in combination with additive promoters. Agents such as tributylmethylammonium or tetraphenylphosphonium chloride were among the bes
Mild fluorination of chloropyridines with in situ generated anhydrous tetrabutylammonium fluoride
Allen, Laura J.,Muhuhi, Joseck M.,Bland, Douglas C.,Merzel, Rachel,Sanford, Melanie S.
, p. 5827 - 5833 (2014/07/08)
This paper describes the fluorination of nitrogen heterocycles using anhydrous NBu4F. Quinoline derivatives as well as a number of 3- and 5-substituted pyridines undergo high-yielding fluorination at room temperature using this reagent. These results with anhydrous NBu4F compare favorably to traditional halex fluorinations using alkali metal fluorides, which generally require temperatures of ≥100 °C.
