1610881-37-2

Basic information

• Product Name: (2-cycloocten-1-yloxy)benzene
• CAS NO: 1610881-37-2
• Molecular Weight: 202.296
• Mol File: 1610881-37-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-cycloocten-1-yloxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (2-cycloocten-1-yloxy)benzene(1610881-37-2)
• EPA Substance Registry System: (2-cycloocten-1-yloxy)benzene(1610881-37-2)

Safety Data

• Hazardous Substances Data: 1610881-37-2(Hazardous Substances Data)

Upstream product

• 7422-06-2 1-bromo-2-cyclooctene 
• 108-95-2 phenol 
• 3212-75-7 2-cycloocten-1-ol 

Downstream Products

• 108-95-2 phenol 
• 86997-05-9 C₁₂H₁₈N₂ 

Relevant articles and documents

Rearrangements of Cycloalkenyl Aryl Ethers

Rearrangement reactions of cycloalkenyl phenol and naphthyl ethers and the acid-catalyzed cyclization of the resulting product were investigated. Claisen rearrangement afforded 2-substituted phenol and naphthol derivatives. Combined Claisen and Cope rearrangement resulted in the formation of 4-substituted phenol and naphthol derivatives. In the case of cycloocthylphenyl ether the consecutive Claisen and Cope rearrangements were followed by an alkyl migration. The mechanism of this novel rearrangement reaction is also discussed.

ACTIVATABLE LIPOSOMES

Disclosed are reactive liposome, comprising a lipid bilayer enclosing a cavity, wherein the bilayer comprises a linkage to an eight-membered non-aromatic cyclic alkenylene group, preferably a cyclooctene group, and more preferably a trans-cyclooctene group. The liposomes are use in a kit comprising the liposome linked, directly or indirectly, to a Trigger, and an Activator for the Trigger, wherein the Trigger comprises an eight-membered non-aromatic cyclic alkenylene group, and the Activator comprises a diene.

BIO-ORTHOGONAL DRUG ACTIVATION

Disclosed is a kit for the administration and activation of a Prodrug. The kit comprises a Masking Moiety linked, directly or indirectly, to a Trigger moiety, which in turn is linked to a Drug, and an Activator for the Trigger moiety. The Trigger moiety comprises a dienophile and the Activator comprises a diene, whereby the dienophile is an eight-membered non- aromatic cyclic alkenylene group, preferably a cyclooctene group, and more preferably a trans-cyclooctene group. The Trigger and the Activator undergo a fast, bio-orthogonal reaction resulting in the release of the Masking Moiety, and activation of the drug.