16112-24-6

Basic information

• Product Name: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-
• Synonyms: 3-phenyl-5-p-tolyl-[1,2,4]oxadiazole;3-(4-methyl)phenyl-5-phenyl-[1,2,4]oxadiazole;3-phenyl-5-(4-methylphenyl)-1,2,4-oxadiazole;1,2,4-Oxadiazole,5-(4-methylphenyl)-3-phenyl;3-Phenyl-5-p-tolyl-[1,2,4]oxadiazol
• CAS NO: 16112-24-6
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol File: 16112-24-6.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-(16112-24-6)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 5-(4-methylphenyl)-3-phenyl-(16112-24-6)

Safety Data

• Hazardous Substances Data: 16112-24-6(Hazardous Substances Data)

Upstream product

• 188118-36-7 N,N-Diethyl-N'-hydroxy-4-methyl-benzamidine 
• 13222-85-0 p-methylbenzoic anhydride 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 106-42-3 para-xylene 
• 1670-14-0 benzamidine monohydrochloride 
• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 698-16-8 benzohydroximoyl chloride 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 14062-78-3 N,N-dimethyl-4-toluamide 
• 104-84-7 para-methylbenzylamine 
• 68167-55-5 benzimidoyl-p-toluoyl-amine 
• 99-94-5 p-Toluic acid 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 65965-65-3 4-[s-triazolo[1,5-a]pyrid-2-yl]-4'-(3-phenyl-1,2,4-oxadiazol-5-yl)-stilbene 
• 68699-90-1 3-{4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-benzo[d]isoxazole 
• 72094-38-3 4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-benzaldehyde 
• 72093-55-1 5-{4-[2-chloro-4-(4,5-diphenyl-oxazol-2-yl)-trans-styryl]-phenyl}-3-phenyl-[1,2,4]oxadiazole 
• 72093-86-8 2-{3-chloro-4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-benzooxazole 
• 72093-85-7 5-methyl-2-{4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-styryl]-phenyl}-benzooxazole 
• 64893-57-8 2-{4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-benzooxazole 
• 72094-15-6 5-{4-[4-(5-biphenyl-4-yl-[1,3,4]oxadiazol-2-yl)-2-chloro-trans-styryl]-phenyl}-3-phenyl-[1,2,4]oxadiazole 
• 72094-14-5 5-(4-{2-chloro-4-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-3-phenyl-[1,2,4]oxadiazole 
• 72094-13-4 5-(4-{2-chloro-4-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-trans-styryl}-phenyl)-3-phenyl-[1,2,4]oxadiazole 
• 72094-12-3 5-{4-[2-chloro-4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-trans-styryl]-phenyl}-3-phenyl-[1,2,4]oxadiazole 
• 72094-22-5 2-{3-chloro-4-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-2H-benzo[1,2,3]triazole 
• 72094-39-4 4-chloro-N-[4-(3-phenyl-[1,2,4]oxadiazol-5-yl)-benzylidene]-aniline 
• 72094-37-2 5-(4-bromomethyl-phenyl)-3-phenyl-[1,2,4]oxadiazole 

Relevant articles and documents

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Convenient one-pot synthesis of 1,2,4-oxadiazoles and 2,4,6-triarylpyridines using graphene oxide (GO) as a metal-free catalyst: Importance of dual catalytic activity

A convenient and efficient process for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles and 2,4,6-triarylpyridines has been described using an inexpensive, environmentally benign, metal-free heterogeneous carbocatalyst, graphene oxide (GO). GO plays a dual role of an oxidizing agent and solid acid catalyst for synthesizing 1,2,4-oxadiazoles and triarylpyridines. This dual catalytic activity of GO is due to the presence of oxygenated functional groups which are distributed on the nanosheets of graphene oxide. A broad scope of substrate applicability and good sustainability is offered in this developed protocol. The results of a few control experiments reveal a plausible mechanism and the role of GO as a catalyst was confirmed by FTIR, XRD, SEM, and HR-TEM analysis.