16112-34-8

Basic information

• Product Name: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole
• Synonyms: 1H-pyrazole, 3-(4-methylphenyl)-1,5-diphenyl-; 3-(4-Methylphenyl)-1,5-diphenyl-1H-pyrazole
• CAS NO: 16112-34-8
• Molecular Formula: C₂₂H₁₈N₂
• Molecular Weight: 310.3917
• Mol File: 16112-34-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 487.3°C at 760 mmHg
• Flash Point: 248.5°C
• Density: 1.08g/cm³
• Vapor Pressure: 3.57E-09mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole(16112-34-8)
• EPA Substance Registry System: 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole(16112-34-8)

Safety Data

• Hazardous Substances Data: 16112-34-8(Hazardous Substances Data)

Usage

General Description

3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole is a chemical compound that belongs to the class of pyrazole derivatives. It is composed of a pyrazole ring with a 4-methylphenyl and two phenyl groups attached at different positions. This chemical has potential applications in the field of pharmaceuticals and materials science due to its unique structure and properties. It could potentially be used in the development of new drugs or as a building block for creating novel materials with specific characteristics. Further research and studies are needed to fully understand and explore the potential uses and properties of 3-(4-methylphenyl)-1,5-diphenyl-1H-pyrazole.

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Relevant articles and documents

Synthesis of pyrazoles by a one-pot tandem cyclization-dehydrogenation approach on Pd/C/K-10 catalyst

A novel one-pot synthesis of substituted pyrazoles from chalcones and hydrazines via a tandem cyclization-dehydrogenation approach is described. This process is based on the use of a bifunctional noble-metal/solid-acid catalyst, Pd/C/K-10 montmorillonite

One-pot regioselective synthesis of substituted pyrazoles and isoxazoles in PEG-400/water medium by Cu-free nano-Pd catalyzed sequential acyl Sonogashira coupling-intramolecular cyclization

Catalyst efficacy of in situ generated Pd-nanoparticles (PdNPs) in the regioselective one-pot synthesis of 3,5-di & 3,4,5-trisubstituted pyrazoles and 3,5-disubstituted isoxazoles in environmentally benign PEG-400/H2O medium, which involves the sequential (i) Cu-free acyl-Sonogashira coupling (ASC) and (ii) intramolecular ynone-amine cyclization under PTC conditions was described. The results of controlled experiments support the operation of two sequential catalytic cycles (ASC/cyclization) and achievement of complementary/opposite regioselectivity via ynone-bound palladium in a one-pot approach. Moreover, the in situ PdNPs recovered after the first catalytic cycle of the one-pot reaction sequence have been reused again five times successively. Besides, prior to the above studies, the efficacy of some common Pd-N-heterocyclic carbene (Pd-NHC) complexes in catalyzing the same one-pot two-step reaction sequence (Cu-free ASC/cyclization) both in water and organic solvents was also optimized. In situ generation of PdNPs from above Pd-NHCs in water was also identified, but they are not reusable due to their large size distribution.

Radical Enamination of Vinyl Azides: Direct Synthesis of N-Unprotected Enamines

An electron-withdrawing-group-generable radical-induced enamination of vinyl azides is reported, which results in a variety of β-functionalized N-unprotected enamines in a stereoselective manner. A plausible mechanism involving an unusual 1,3-H transfer of in situ generated iminyl radical intermediate was proposed on the basis of experimental results and DFT calculations.