1611446-66-2

Basic information

• Product Name: 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid
• Synonyms: 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid
• CAS NO: 1611446-66-2
• Molecular Weight: 493.01
• Mol File: 1611446-66-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid(1611446-66-2)
• EPA Substance Registry System: 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-hexadecanoic acid(1611446-66-2)

Safety Data

• Hazardous Substances Data: 1611446-66-2(Hazardous Substances Data)

Upstream product

• 1611446-67-3 ethyl 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoate 
• 85258-69-1 ethyl 16-hydroxyhexadecanoate 
• 506-13-8 16-hydroxyhexadecanoic acid 
• 327-78-6 4-chloro-3-(trifluoromethyl)phenyl isocyanate 

Relevant articles and documents

A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin to Promote Killing of Breast Cancer Cells

Cancer cell mitochondria are promising anticancer drug targets because they control cell death and are structurally and functionally different from normal cell mitochondria. We synthesized arylurea fatty acids and found that the analogue 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid (13b) decreased proliferation and activated apoptosis in MDA-MB-231 breast cancer cells in vitro and in vivo. In mechanistic studies 13b emerged as the prototype of a novel class of mitochondrion-targeted agents that deplete cardiolipin and promote cancer cell death.