1611478-22-8

Basic information

• Product Name: 1-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydroquinoline
• Synonyms: 1-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydroquinoline
• CAS NO: 1611478-22-8
• Molecular Weight: 291.316
• Mol File: 1611478-22-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydroquinoline(1611478-22-8)
• EPA Substance Registry System: 1-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydroquinoline(1611478-22-8)

Safety Data

• Hazardous Substances Data: 1611478-22-8(Hazardous Substances Data)

Upstream product

• 91-22-5 quinoline 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Relevant articles and documents

Reductive Alkylation of Quinolines to N-Alkyl Tetrahydroquinolines Catalyzed by Arylboronic Acid

A boronic acid catalyzed one-pot tandem reduction of quinolines to tetrahydroquinolines followed by reductive alkylation by the aldehyde has been demonstrated. This step-economcial synthesis of N-alkyl tetrahydroquinolines has been achieved directly from readily available quinolines, aldehydes, and Hantzsch ester under mild reaction conditions. The mechanistic study demonstrates the unique behavior of organoboron catalysts as both Lewis acids and hydrogen-bond donors.