1611489-74-7

Basic information

• Product Name: (2Z,6E,10E)-12-(acetylthio)-7,11-dimethyl-5-(phenylsulfonyl)dodeca-2,6,10-trien-1-yl 2,3,4-tri-Oacetyl-6-deoxy-6-azido-α-D-mannopyranoside
• Synonyms: (2Z,6E,10E)-12-(acetylthio)-7,11-dimethyl-5-(phenylsulfonyl)dodeca-2,6,10-trien-1-yl 2,3,4-tri-Oacetyl-6-deoxy-6-azido-α-D-mannopyranoside
• CAS NO: 1611489-74-7
• Molecular Weight: 735.877
• Mol File: 1611489-74-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2Z,6E,10E)-12-(acetylthio)-7,11-dimethyl-5-(phenylsulfonyl)dodeca-2,6,10-trien-1-yl 2,3,4-tri-Oacetyl-6-deoxy-6-azido-α-D-mannopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z,6E,10E)-12-(acetylthio)-7,11-dimethyl-5-(phenylsulfonyl)dodeca-2,6,10-trien-1-yl 2,3,4-tri-Oacetyl-6-deoxy-6-azido-α-D-mannopyranoside(1611489-74-7)
• EPA Substance Registry System: (2Z,6E,10E)-12-(acetylthio)-7,11-dimethyl-5-(phenylsulfonyl)dodeca-2,6,10-trien-1-yl 2,3,4-tri-Oacetyl-6-deoxy-6-azido-α-D-mannopyranoside(1611489-74-7)

Safety Data

• Hazardous Substances Data: 1611489-74-7(Hazardous Substances Data)

Upstream product

• 106-24-1 Geraniol 
• 139978-81-7 methyl 2,3-O-isopropylidene-α-D-mannopyranoside 4,6-sulfite 
• 617-04-9 (2R,3S,4S,5S,6S)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 142619-50-9 C₁₆H₂₁BrO₂S 
• 95763-61-4 3,7-dimethyl-1-(phenylsulfonyl)-8-hydroxy-2(E),6(E)-octadiene 
• 338776-51-5 (2E,6E)-2,6-dimethyl-8-(phenylsulfonyl)octa-2,6-dien-1-al 
• 56691-80-6 geranyl phenyl sulfone 
• 6138-90-5 trans-geranyl bromide 
• 1611489-68-9 4-bromobut-2-en-1-yl-6-deoxy-6-azido-2,3,4-tri-O-acetyl-α-D-mannopyranoside 
• 1611489-73-6 S-(2E,6E)-2,6-dimethyl-8-(phenylsulfonyl)octa-2,6-dien-1-yl ethanethioate 
• 210170-40-4 1,2,3,4-tetra-O-acetyl-6-azido-6-deoxy-α-D-mannopyranoside 
• 18439-61-7 methyl 2,3,4-tri-O-acetyl-6-azido-6-deoxy-α-D-mannopyranoside 
• 66224-56-4 methyl 6-azido-6-deoxy-α-D-mannopyranoside 
• 139978-82-8 methyl-2,3-O-isopropylidene-4,6-cyclic sulfate-α-D-mannopyranoside 

Relevant articles and documents

Gold nanoparticles decorated with mannose-6-phosphate analogues

Herein, the preparation of neoglycoconjugates bearing mannose-6-phosphate analogues is described by: (a) synthesis of a cyclic sulfate precursor to access the carbohydrate head-group by nucleophilic displacement with an appropriate nucleophile; (b) introduction of spacers on the mannose-6-phosphate analogues via Huisgen's cycloaddition, the Julia reaction, or the thiol-ene reaction under ultrasound activation. With the resulting compounds in hand, gold nanoparticles could be functionalized with various carbohydrate derivatives (glycoconjugates) and then tested for angiogenic activity. It was observed that the length and flexibility of the spacer separating the sugar analogue from the nanoparticle have little influence on the biological response. One particular nanoparticle system substantially inhibits blood vessel growth in contrast to activation by the corresponding monomeric glycoconjugate, thereby demonstrating the importance of multivalency in angiogenic activity.