161282-72-0

Basic information

• Product Name: Carbamic acid, [(1S,2R)-2-hydroxy-3-nitro-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester
• CAS NO: 161282-72-0
• Molecular Formula: C15H22N2O5
• Molecular Weight: 310.35
• Mol File: 161282-72-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S,2R)-2-hydroxy-3-nitro-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S,2R)-2-hydroxy-3-nitro-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester(161282-72-0)
• EPA Substance Registry System: Carbamic acid, [(1S,2R)-2-hydroxy-3-nitro-1-(phenylmethyl)propyl]-, 1,1-dimethylethyl ester(161282-72-0)

Safety Data

• Hazardous Substances Data: 161282-72-0(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 72155-45-4 Boc-L-phenylalaninal 
• 7535-56-0 N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester 
• 64411-37-6 N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenyl ester 
• 174302-72-8 (S)-3-tert-butoxycarbonylamino-1-nitro-4-phenyl-2-butanone 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 1422208-16-9 C₃₆H₅₁N₅O₃ 
• 1422208-15-8 C₃₅H₄₇N₅O₃ 
• 1422208-14-7 C₃₄H₄₇N₅O₃ 
• 1422208-13-6 C₃₄H₄₅N₅O₃ 
• 1422208-12-5 C₃₇H₅₃N₅O₃ 
• 1422208-11-4 C₃₆H₄₉N₅O₃ 
• 1422253-17-5 C₄₁H₅₉N₅O₃ 
• 1422207-70-2 C₂₇H₃₈N₄O₂ 
• 388062-34-8 N₁-[(1S,2R)-1-benzyl-3-(cyclohexylamino)-2-hydroxypropyl]-N₃,N₃-dipropylisophthalamide 
• 388063-96-5 N₁-[(1S,2R)-1-benzyl-3-(2,3-dihydro-1H-inden-2-ylamino)-2-hydroxypropyl]-N₃,N₃-dipropylisophthalamide 
• 388062-29-1 N₁-[(1S,2R)-1-benzyl-3-(2,3-dihydro-1H-inden-1-ylamino)-2-hydroxypropyl]-N₃,N₃-dipropylisophthalamide 
• 660431-13-0 N¹-((2S,3R)-4-amino-3-hydroxy-1-phenylbutan-2-yl)-N³,N³-dipropylisophthalamide 
• 388065-62-1 N₁-{(1S,2R)-1-benzyl-2-hydroxy-3-[(2-phenylethyl)amino]propyl}-N₃,N₃-dipropylisophthalamide 
• 388062-43-9 N₁-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-phenylpropyl)amino]propyl}-N₃,N₃-dipropylisophthalamide 

Relevant articles and documents

Stereoselective synthesis of the key intermediates of the HIV protease inhibitor fosamprenavir and its diastereomer

Highly stereoselective Henry reaction has been used in the synthesis of the fosamprenavir precursor (2S,3R)-N-tert-butyloxycarbonyl-2-amino-3-hydroxy-1- phenyl-4-nitrobutane and its 2S,3S diasteromer from N-tert-butyloxycarbonyl-(S)- phenylalaninal and ni

re- and si-face-selective nitroaldol reactions catalyzed by a rigid chiral quaternary ammonium salt: A highly stereoselective synthesis of the HIV protease inhibitor amprenavir (Vertex 478)

Either amprenavir (1) or its C(2) diastereomer can be synthesized in a simple way by the use of a nitroaldol reaction carried out in the presence of one or the other of the two ammonium ions 2. The 1,3-diamino-2-hydroxypropyl structural element of 1 is also found in many other peptidomimetics and HIV protease inhibitors. Described here is a new strategy for possible application to direct and stereocontrolled synthesis of such compounds.

Diastereoselective catalytic asymmetric nitroaldol reaction utilizing rare earth-Li-(R)-BINOL complex. A highly efficient synthesis of norstatine

Rare earth-Li-BINOL complexes were used to catalyze nitroaldol reactions of optically active α-amino-aldehydes with nitromethane in a highly diastereoselective manner. A typical adduct, (2S, 3S)-3-phtaloylamino-2-hydroxy-1-nitro-4-phenylbutane was conveni