1612853-60-7

Basic information

• Product Name: 2-(2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-formylphenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile
• Synonyms: 2-(2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-formylphenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile
• CAS NO: 1612853-60-7
• Molecular Weight: 606.659
• Mol File: 1612853-60-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-formylphenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-formylphenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile(1612853-60-7)
• EPA Substance Registry System: 2-(2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-formylphenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile(1612853-60-7)

Safety Data

• Hazardous Substances Data: 1612853-60-7(Hazardous Substances Data)

Upstream product

• 1360056-99-0 4-(5-(azetidin-1-ylmethyl)-1-methyl-1H-pyrazol-3-ylamino)-6-chloro-2-methylpyridazin-3(2H)-one 
• 1227210-49-2 5-(azetidin-1-ylmethyl)-1-methyl-1H-pyrazol-3-amine 
• 1227210-48-1 5-(azetidin-1-ylmethyl)-1-methyl-3-nitro-1H-pyrazole 
• 1227210-47-0 5-(bromomethyl)-1-methyl-3-nitro-1H-pyrazole 
• 1227210-46-9 (1-methyl-3-nitro-1H-pyrazol-5-yl)methanol 
• 1360056-35-4 2-[2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl]-2-methylpropionitrile 
• 1612853-58-3 C₁₉H₂₉BN₆O₃ 
• 1360056-34-3 2-(8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile 
• 1360056-33-2 4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide 
• 1360056-32-1 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide 
• 1360056-31-0 4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzoic acid 
• 1360056-30-9 2-(4-(2-cyanoporopyl-2-yl)-2-fluoro-6-methylphenyl)-3,4,4-trimethyl-4,5-dihydro-1,3-oxazole-3-ium iodide 
• 1360056-29-6 2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile 
• 1360056-28-5 2-(2,4-difluoro-6-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole 

Downstream Products

• 1360055-72-6 2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile 

Relevant articles and documents

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3- hydroxymethyl-4-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-6-ylamino)- 6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1- ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2- hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2- ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.