1613028-81-1 Usage
Description
SR-9243 is a cell-permeable liver X receptor (LXR) inverse agonist that serves as a potent modulator of lipid, cholesterol, and carbohydrate metabolism and homeostasis. It is characterized by its ability to induce LXR-corepressor interaction at nanomolar concentrations, leading to a reduction in cancer cell viability without cytotoxicity against non-malignant cells. SR-9243 effectively disrupts the Warburg effect in cancer cells, suppressing the expression of glycolytic and lipogenic genes, and reducing glycolytic metabolites and lipid production.
Uses
Used in Cancer Treatment:
SR-9243 is used as a therapeutic agent for targeting cancer cells by disrupting the Warburg effect, which is a metabolic characteristic of cancer cells. It suppresses the expression of glycolytic and lipogenic genes, leading to a reduction in glycolytic metabolites and lipid production, ultimately killing cancer cells.
Used in Inhibiting Lipid Production:
SR-9243 is used as a regulator to inhibit lipid production in cancer cells, which is a critical factor in their survival and proliferation. By reducing lipid production, SR-9243 contributes to the suppression of cancer cell growth and the overall control of the disease.
Used in Drug Development for Metabolic Disorders:
Given its ability to modulate lipid, cholesterol, and carbohydrate metabolism, SR-9243 can be used as a starting point for the development of new drugs targeting metabolic disorders related to dysregulation of these pathways. Its potential application in this area could lead to novel treatments for conditions such as obesity, diabetes, and cardiovascular diseases.
References
1) Flaveny?et al. (2015),?Broad anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis; Cancer Cell,?28?42
Check Digit Verification of cas no
The CAS Registry Mumber 1613028-81-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,3,0,2 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1613028-81:
(9*1)+(8*6)+(7*1)+(6*3)+(5*0)+(4*2)+(3*8)+(2*8)+(1*1)=131
131 % 10 = 1
So 1613028-81-1 is a valid CAS Registry Number.
1613028-81-1Relevant articles and documents
Synthesis and structure activity relationship of the first class of LXR inverse agonists
Elgendy, Bahaa,Griffett, Kristine,Hegazy, Lamees,Di Fruscia, Paolo,Sample, Kirby,Schoepke, Emmalie,Kamenecka, Theodore M.,Burris, Thomas P.
, (2021/12/14)
Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play significant role in lipid and cholesterol metabolism. Moreover, they are key regulators of several inflammatory pathways. Pharmacological modulation of LXRs holds great pot
