1613289-76-1

Basic information

• Product Name: dimethyl 3,4-bis(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,5-dicarboxylate
• CAS NO: 1613289-76-1
• Molecular Weight: 471.356
• Mol File: 1613289-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl 3,4-bis(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3,4-bis(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,5-dicarboxylate(1613289-76-1)
• EPA Substance Registry System: dimethyl 3,4-bis(4-(trifluoromethyl)phenyl)-1H-pyrrole-2,5-dicarboxylate(1613289-76-1)

Safety Data

• Hazardous Substances Data: 1613289-76-1(Hazardous Substances Data)

Upstream product

• 174152-11-5 (S)-2-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid methyl ester 

Relevant articles and documents

Cu/Mn Co-oxidized cyclization for the synthesis of highly substituted pyrrole derivatives from amino acid esters: A strategy for the biomimetic syntheses of lycogarubin c and chromopyrrolic acid

An effective and concise approach to synthesis of tetrasubstituted pyrroles from readily available amino acid esters by the promotion of Cu(OAc) 2 in conjunction with Mn(OAc)3 has been developed. This reaction proceeds through multiple dehydrogenations, deamination, and oxidative cyclization. This oxidized system tolerates substrates bearing various electron-donating or electron-withdrawing groups. With this methodology, several key intermediates of natural products have been effectively prepared, and the total syntheses of lycogarubin C and chromopyrrolic acid have been completed in high efficiency.