1613333-40-6

Basic information

• Product Name: 4-(4-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester
• CAS NO: 1613333-40-6
• Molecular Weight: 633.51
• Mol File: 1613333-40-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(4-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester(1613333-40-6)
• EPA Substance Registry System: 4-(4-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester(1613333-40-6)

Safety Data

• Hazardous Substances Data: 1613333-40-6(Hazardous Substances Data)

Upstream product

• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 877399-73-0 tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1562305-13-8 4-(4-(3-iodo-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 98-09-9 benzenesulfonyl chloride 
• 1562305-10-5 4-(4-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 877399-74-1 tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 

Downstream Products

• 1613333-43-9 4-(4-(3-((2,5-dichlorophenyl)ethynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester 
• 1613332-90-3 3-((2,5-dichlorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613333-44-0 4-(4-(3-((2,5-difluorophenyl)ethynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine1-carboxylic acid tert-butyl ester 
• 1613332-92-5 3-((2,5-difluorophenyl)ethynyl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1613333-41-7 4-(4-(1-(phenylsulfonyl)-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Alkenyl compound and its method and use thereof

The invention provides a new substituted alkenyl compound, pharmaceutically acceptable salts of the new substituted alkenyl compound, a medicinal preparation of the new substituted alkenyl compound, and application of the new substituted alkenyl compound, the pharmaceutically acceptable salts and the medicinal preparation of the new substituted alkenyl compound in aspects of regulating the activity of protein kinase and regulating the intercellular or intracellular signal response. The invention also relates to a medicament composition containing the compound at the same time, and relates to a method for treating high-proliferative diseases of mammals especially the human by using the medicament composition.

ALKENYL COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted alkenyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.