1613377-11-9Relevant articles and documents
Total synthesis of (+)-cylindradine A
Iwata, Makoto,Kanoh, Kyohei,Imaoka, Takuya,Nagasawa, Kazuo
, p. 6991 - 6994 (2014)
Cylindradines A and B, members of the polycyclic pyrrole-imidazole alkaloids (PIAs), are the only congeners bearing a 3-carbamoylpyrrole unit among the PIAs. In this communication, we described a total synthesis of (+)-cylindradine A based on intramolecular Friedel-Crafts type cyclization of pyrrole-aldehyde and oxidative cyclization of tricyclic pyrrolopyrrolidine- guanidine with hypervalent iodine to construct the cyclic guanidine structure including the N,N′-aminal moiety. the Partner Organisations 2014.