16137-56-7Relevant articles and documents
Efficient trans-diaxial hydroxylation of Δ5-steroids
Carvalho, Jo?o F.S.,Silva, M. Manuel Cruz,Sá e Melo, M. Luisa
experimental part, p. 2455 - 2462 (2010/06/14)
A convenient, fast, and high-yielding process to synthesize 5α,6β-dihydroxysteroids directly from the correspondent Δ5-steroids is reported. The reaction protocol consists in the conjugation of a readily available and stable oxidant, magnesium bis(monoperoxyphthalate) hexahydrate, with the non-toxic bismuth(III) triflate in acetone to afford the trans-diaxial hydroxylation product in a stepwise manner and in excellent yields.
Gram-scale chromatographic purification of β-sitosterol: Synthesis and characterization of β-sitosterol oxides
Zhang, Xin,Geoffroy, Philippe,Miesch, Michel,Julien-David, Diane,Raul, Francis,Aoude-Werner, Dalal,Marchioni, Eric
, p. 886 - 895 (2007/10/03)
An effective purification method for β-sitosterol was developed starting from a commercial source of a phytosterol mixture using preparative adsorption column chromatography. β-Sitosterol (≥95% purity) was obtained on a gram-scale. Thus, the synthesis of six β-sitosterol oxides, including 7α-hydroxy, 7β-hydroxy, 5,6α-epoxy, 5,6β-epoxy, 7-keto, and 5α,6β-dihydroxysitosterol, were successfully carried out. The spectral characteristics of all the synthetic intermediates and target compounds (～95% purity) were well-documented.
Biological evaluation in vivo and in vitro of selected 5-alpha-cholestane-3-beta, 5-alpha, 6-beta-triol analogs as hypocholesterolemic agents.
Witiak,Parker,Brann,Dempsey,Ritter,Connor,Brahmankar
, p. 216 - 222 (2007/10/14)
-
