1613810-21-1Relevant articles and documents
Palladium(II)-catalyzed cyclization of heterocyclic ketene aminals with (E)-ethyl 2,3-diiodoacrylates: Selective synthesis of bicyclic pyrroles and bicyclic pyridones
Hu, Ling,Wang, Kai-Min,Zhao, Min,Lin, Xin-Rong,Zhu, Hong-You,Yan, Sheng-Jiao,Lin, Jun
, p. 4478 - 4484 (2014/06/10)
A concise and efficient synthesis of novel bicyclic pyrroles has been achieved by PdCl2-catalyzed cyclic condensation of six-membered heterocyclic ketene aminals (HKAs) or seven-membered HKAs with ethyl 2,3-diiodoacrylate and diethyl 2,3-diiodofumarate in the presence of Cs 2CO3, respectively. A series of novel bicyclic pyridones have also been obtained via five-membered HKAs with diethyl 2,3-diiodofumarate under the optimized conditions in moderate yields. These reactions are the first application of a transition metal to catalyze the building blocks HKAs to form the bicyclic pyrrole library via condensation reaction.