161397-68-8 Usage
Description
1H-Indole-5-carbonyl chloride (9CI) is a chemical compound with the molecular formula C9H6ClNO. It is a derivative of indole and is commonly used in organic synthesis as a versatile building block for the preparation of various pharmaceuticals and agrochemicals. 1H-Indole-5-carbonyl chloride (9CI) is a reactive compound known for its ability to undergo nucleophilic aromatic substitution reactions, making it useful in the production of a wide range of indole derivatives. It is also an important intermediate in the synthesis of various bioactive compounds, including drugs and natural products. Due to its synthetic versatility and biological importance, 1H-Indole-5-carbonyl chloride (9CI) is a valuable chemical in the field of organic chemistry.
Uses
Used in Pharmaceutical Industry:
1H-Indole-5-carbonyl chloride (9CI) is used as a building block for the synthesis of various pharmaceuticals, due to its ability to undergo nucleophilic aromatic substitution reactions and its role as an intermediate in the production of bioactive compounds.
Used in Agrochemical Industry:
1H-Indole-5-carbonyl chloride (9CI) is used as a key intermediate in the development of agrochemicals, contributing to the creation of effective products for agricultural applications.
Used in Organic Synthesis:
1H-Indole-5-carbonyl chloride (9CI) is used as a versatile reagent in organic synthesis, enabling the production of a wide range of indole derivatives for various applications across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 161397-68-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,3,9 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 161397-68:
(8*1)+(7*6)+(6*1)+(5*3)+(4*9)+(3*7)+(2*6)+(1*8)=148
148 % 10 = 8
So 161397-68-8 is a valid CAS Registry Number.
161397-68-8Relevant articles and documents
Structure-Activity Relationship for the Oxadiazole Class of Antibacterials
Boudreau, Marc A.,Ding, Derong,Meisel, Jayda E.,Janardhanan, Jeshina,Spink, Edward,Peng, Zhihong,Qian, Yuanyuan,Yamaguchi, Takao,Testero, Sebastian A.,O'Daniel, Peter I.,Leemans, Erika,Lastochkin, Elena,Song, Wei,Schroeder, Valerie A.,Wolter, William R.,Suckow, Mark A.,Mobashery, Shahriar,Chang, Mayland
supporting information, p. 322 - 326 (2019/10/16)
A structure-activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro toxicity, plasma protein binding, pharmacokinetics (PK), and a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Oxadiazole 72c shows potent in vitro antibacterial activity, exhibits low clearance, a high volume of distribution, and 41% oral bioavailability, and shows efficacy in mouse models of MRSA infection.
Heterocyclic N-acetonylbenzamides and their use as fungicides
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Page 18, (2010/01/31)
Certain N-acetonylbenzamides and their use as fungicides are disclosed. The N-acetonylbenzamides disclosed contain a heterocyclic ring fused to an aromatic ring. These compounds are particularly effective against phytopathogenic fungi of the class Oomycetes. Also disclosed is a method for controlling phytopathogenic fungi by applying one or more of the heterocyclic N-acetonylbenzamides of the present invention, optionally with one or more additional fungicidal compounds.