161620-93-5

Basic information

• Product Name: tert-butyl 3-hydroxy-5-methylphenylcarbamate
• Synonyms: tert-butyl 3-hydroxy-5-methylphenylcarbamate
• CAS NO: 161620-93-5
• Molecular Weight: 223.272
• Mol File: 161620-93-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-hydroxy-5-methylphenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-hydroxy-5-methylphenylcarbamate(161620-93-5)
• EPA Substance Registry System: tert-butyl 3-hydroxy-5-methylphenylcarbamate(161620-93-5)

Safety Data

• Hazardous Substances Data: 161620-93-5(Hazardous Substances Data)

Upstream product

• 76619-89-1 3-amino-5-methylphenol 
• 504-15-4 orcinol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1092394-22-3 tert-butyl {2-methyl-5-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate 
• 1092394-72-3 tert-butyl [5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]carbamate 
• 1092394-24-5 ethyl {[(5-{3-[(tert-butoxycarbonyl)amino]-4-methylphenoxy}pyridin-2-yl)amino]carbonothioyl}carbamate 
• 1092391-98-4 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]cyclobutanecarboxamide 
• 1092391-91-7 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2-methylpropanecarboxamide 
• 1092391-89-3 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-5-carboxamide 
• 1092391-96-2 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-4-carboxamide 
• 1092391-95-1 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-3-chloro-4-methylthiophene-2-carboxamide 
• 1092391-88-2 N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2,5-dimethyl-1,3-thiazole-4-carboxamide 
• 1092394-73-4 N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide 
• 1092394-71-2 tert-butyl {5-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-2-methylphenyl}carbamate 
• 1092394-23-4 tert-butyl {5-[(6-aminopyridin-3-yl)oxy]-2-methylphenyl}carbamate 
• 137039-32-8 [2-(5-Hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-methoxymethoxy-5-methyl-phenyl]-carbamic acid tert-butyl ester 
• 212067-22-6 2-[3-(3-Amino-5-methyl-phenoxy)-propyl]-isoindole-1,3-dione 

Relevant articles and documents

Amidino derivatives and their use as thrombin inhibitors

There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Diarylsulfonamides as selective, non-peptidic thrombin inhibitors

Based on the structures of aminopyridine thrombin inhibitors (1), a series of aminoalkyl- and guanidinoalkyl-substituted diarylsulfonamides were prepared. The most potent derivative, N-[3-(4-guanidinobutoxy)-5-methyl- phenyl]-benzenesulfonamide (6c) had Ki = 0.18 μM for thrombin and did not inhibit trypsin, plasmin, or factor Xa. Comparison of the X-ray structures of the thrombin / 1b and the thrombin / 6e complexes revealed important aspects which govern the binding of such diarylsulfonamides to thrombin.

Synthesis of the benzo[b] carbazoloquinone with the structure proposed for prekinamycin

The synthesis of the N-cyano benzo[b]carbazolequinone with the structure proposed for prekinamycin has been achieved by palladium and copper catalyzed coupling of a 2-bromonaphthoquinone with an arylstannane followed by ring closure, N-cyanation, and demethylation. Unexpectedly, the ring closure reaction gave also a regioisomer by an unprecedented rearrangement reaction.