1616246-32-2

Basic information

• Product Name: (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide
• Synonyms: (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide
• CAS NO: 1616246-32-2
• Molecular Weight: 409.528
• Mol File: 1616246-32-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide(1616246-32-2)
• EPA Substance Registry System: (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((tetrahydro-2H-pyran-4-yl)amino)benzamide(1616246-32-2)

Safety Data

• Hazardous Substances Data: 1616246-32-2(Hazardous Substances Data)

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 1616077-51-0 (S)-1-amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)-propan-2-ol 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 1616064-77-7 (R)-2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific community with in vivo-active tool compound EPZ015666 (GSK3235025) to probe the underlying pharmacology of this key enzyme. Herein, we report the design and optimization strategies employed on an initial hit compound with poor in vitro clearance to yield in vivo tool compound EPZ015666 and an additional potent in vitro tool molecule EPZ015866 (GSK3203591).