1616475-69-4Relevant articles and documents
Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site
Ding, Kejia,Wang, Annie,Boerneke, Mark A.,Dibrov, Sergey M.,Hermann, Thomas
, p. 3113 - 3117 (2014/06/24)
We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The design of the compounds was guided by the co-crystal structure of a benzimidazole viral translation inhibitor in complex with the RNA target. Structure-binding activity relationships of aryl-substituted benzimidazole ligands were established that were consistent with the crystal structure of the translation inhibitor complex.