1616777-96-8Relevant articles and documents
Catalytic hetero-ene reactions of 5-methyleneoxazolines: Highly enantioselective synthesis of 2,5-disubstituted oxazole derivatives
Luo, Weiwei,Zhao, Jiannan,Yin, Chengkai,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
supporting information, p. 7524 - 7526 (2014/07/07)
An efficient catalytic asymmetric hetero-ene reaction of 5-methyleneoxazolines with 1,2-dicarbonyl compounds (including α-ketoesters and glyoxal derivatives) was realized using Ni(ii)-N,N′-dioxide complexes as the catalysts. It provides a rapid, high yielding (up to 99%) route for the preparation of 2,5-disubstituted oxazole derivatives in a highly enantioenriched form (up to >99% ee) under mild conditions. the Partner Organisations 2014.