1616790-45-4

Basic information

• Product Name: (R)-1,2-epoxy-3-(2,3-dimethylphenoxy)propane
• Synonyms: (R)-1,2-epoxy-3-(2,3-dimethylphenoxy)propane
• CAS NO: 1616790-45-4
• Molecular Weight: 178.231
• Mol File: 1616790-45-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-1,2-epoxy-3-(2,3-dimethylphenoxy)propane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,2-epoxy-3-(2,3-dimethylphenoxy)propane(1616790-45-4)
• EPA Substance Registry System: (R)-1,2-epoxy-3-(2,3-dimethylphenoxy)propane(1616790-45-4)

Safety Data

• Hazardous Substances Data: 1616790-45-4(Hazardous Substances Data)

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 526-75-0 2,3-Dimethylphenol 

Downstream Products

• 81584-06-7 (R)-1-(tert-butylamino)-3-(2,3-dimethylphenoxy)-2-propanol 

Relevant articles and documents

A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors

Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates. Hot pockets: Microtuning of the enzyme active pocket gives a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots, and enhanced activity toward bulky substrates was found.