1616828-85-3

Basic information

• Product Name: 6-(3,4,5-trifluorophenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one
• Synonyms: 6-(3,4,5-trifluorophenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one
• CAS NO: 1616828-85-3
• Molecular Weight: 552.741
• Mol File: 1616828-85-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(3,4,5-trifluorophenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3,4,5-trifluorophenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one(1616828-85-3)
• EPA Substance Registry System: 6-(3,4,5-trifluorophenyl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one(1616828-85-3)

Safety Data

• Hazardous Substances Data: 1616828-85-3(Hazardous Substances Data)

Upstream product

• 1616828-53-5 6-bromo-8-methoxy-3H-quinazolin-4-one 
• 1215634-37-9 4-bromo-2-carboxy-6-methoxybenzenamine hydrobromide 
• 1616828-60-4 6-bromo-8-(2-trimethylsilanyl-ethoxymethoxy)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-quinazolin-4-one 
• 1616828-84-2 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-((2-(trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one 
• 170112-66-0 1,2,3-trifluoro-5-iodobenzene 

Downstream Products

• 1616828-83-1 8-hydroxy-6-(3,4,5-trifluorophenyl)quinazolin-4(3H)-one 

Relevant articles and documents

COMT INHIBITORS

The present invention relates to compounds of formula (I), wherein the substituents are described in claim 1 and to the pharmaceutically acceptable salts thereof. These compounds inhibit the enzyme catechol-O-methyltransferase (COMT). The compounds may be used for the treatment of Parkinson's disease, depression, cognitive impairment and motor symptoms, resistant depression, cognitive impairment, mood and negative symptoms of schizophrenia.