1616874-74-8

Basic information

• Product Name: dimethyl 3-(1-iodopent-1-enyl)-2-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate
• CAS NO: 1616874-74-8
• Molecular Weight: 529.355
• Mol File: 1616874-74-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl 3-(1-iodopent-1-enyl)-2-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3-(1-iodopent-1-enyl)-2-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate(1616874-74-8)
• EPA Substance Registry System: dimethyl 3-(1-iodopent-1-enyl)-2-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-isoindol-1-ylphosphonate(1616874-74-8)

Safety Data

• Hazardous Substances Data: 1616874-74-8(Hazardous Substances Data)

Upstream product

• 1616874-14-6 dimethyl (2-(hex-1-ynyl)cyclohex-1-enyl)(4-methoxyphenylamino)methylphosphonate 
• 693-02-7 hex-1-yne 
• 38127-47-8 2-bromocyclohex-1-ene-1-carbaldehyde 
• 104-94-9 4-methoxy-aniline 
• 566190-87-2 2-(hex-1-yn-1-yl)-1-cyclohexenecarboxaldehyde 

Relevant articles and documents

Formation of condensed 1 H-pyrrol-2-ylphosphonates and 1,2-dihydropyridin- 2-ylphosphonates via Kabachnik-fields reaction of acetylenic aldehydes and subsequent 5-exo-dig or 6-endo-dig cyclizations

Kabachnik-Fields reactions of various carbocyclic or heterocyclic acetylenic aldehydes together with subsequent Lewis acid catalyzed cyclizations have been studied. It was found that 5-exo-dig versus 6-endo-dig cyclization mode strongly depends on the structure of starting materials. Thus, nonaromatic acetylenic α-anilinomethylphosphonates underwent gold(III)-catalyzed or iodine-mediated 5-exo-dig cyclization to 1H-pyrrol-2-ylphosphonates. In contrast, electron-withdrawing heteroaromatic substrates formed 1,2-dihydropyridin-2-ylphosphonate ring containing materials via an exclusive 6-endo-dig ring-closure process. The dual mode of cyclization is possible only for α-amino (2-alkynylphenyl)methylphosphonates containing a benzene ring.