161693-38-5Relevant articles and documents
Asymmetric Synthesis of the Key Intermediates Leading to (-)-Aphanorphine and (-)-Eptazocine
Hulme, Alison N.,Henry, Steven S.,Meyers, A. I.
, p. 1265 - 1270 (1995)
The asymmetric syntheses of two key intermediates, 8 and 15, in >99percent ee are reported.These compounds are prepared by diastereofacial addition of lithiodimethylphenylsilane to chiral naphthyloxazolines followed by methyl iodide trapping.The two stere