1616978-98-3

Basic information

• Product Name: C₂₄H₂₆BrN₃O₅
• Synonyms: C₂₄H₂₆BrN₃O₅
• CAS NO: 1616978-98-3
• Molecular Weight: 516.392
• Mol File: 1616978-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₆BrN₃O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₆BrN₃O₅(1616978-98-3)
• EPA Substance Registry System: C₂₄H₂₆BrN₃O₅(1616978-98-3)

Safety Data

• Hazardous Substances Data: 1616978-98-3(Hazardous Substances Data)

Upstream product

• 38770-76-2 1-bromo-2-(prop-2-yn-1-yloxy)benzene 
• 710319-75-8 2α-azidocoronopilin 
• 508-59-8 parthenin 

Relevant articles and documents

Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds

A series of 1,2,3-triazole coronopilin congeners have been designed and synthesized by employing click chemistry approach starting from parthenin and evaluated for their cytotoxicity against a panel of six human cancer cell lines (PC-3, THP-1, HCT-15, HeLa, A-549 and MCF-7). While many compounds exhibited significant anticancer activity, compound 3a, was found to be the most promising analogue in this series with IC50 values of 3.1 μM on PC-3 cell line. Flow-cytometric studies showed that 1,2,3-triazole derivative-3a induce dose dependent apoptosis in the sub G1 phase. This lead molecule-3a was further studied for NF-κB (p65) transcription factor inhibitory activity using Elisa and western blotting analysis which confirmed concentration dependent inhibitory activity against NF-κB, p65 with 80% inhibition in 24 h at 100 μM.