161715-27-1

Basic information

• Product Name: 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine
• Synonyms: 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine;1-(4,5-Dihydrothiazol-2-yl)azetidin-3-ol;1-(4,5-dihydro-2-thiazolyl)-3-Azetidinol
• CAS NO: 161715-27-1
• Molecular Formula: C₆H₁₀N₂OS
• Molecular Weight: 158.2214
• EINECS: -0
• Product Categories: API
• Mol File: 161715-27-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 114-117℃
• Boiling Point: 306.812 °C at 760 mmHg
• Flash Point: 139.355 °C
• Appearance: /
• Density: 1.59
• Storage Temp.: 2-8°C
• PKA: 13.70±0.20(Predicted)
• CAS DataBase Reference: 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine(161715-27-1)
• EPA Substance Registry System: 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine(161715-27-1)

Safety Data

• Hazardous Substances Data: 161715-27-1(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine is a chemical compound with the molecular formula C6H10N2OS. It is a thiazoline derivative with a hydroxy group and an azetidine ring. 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine has potential use in pharmaceutical and medicinal chemistry due to its unique structure and potential biological activity. Thiazoline derivatives have been studied for their anti-tumor, anti-inflammatory, and antimicrobial activities, and the presence of a hydroxy group in this compound could further enhance its pharmacological properties. Further research is required to understand the full potential and applications of 3-Hydroxy-1-(1,3-thiazolin-2-yl)azetidine in various fields, including drug discovery and development.

Upstream product

• 19975-56-5 2-methylsulfanyl-4,5-dihydrothiazoline 
• 18621-18-6 azetion-3-ol hydrochloride 

Downstream Products

• 161715-21-5 Tebipenem 
• 161715-28-2 3-acetylthio-1-(1,3-thiazolin-2-yl)azetidine 
• 161715-20-4 (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-{[1-(2-thiazolin-2-yl)-3-azetidinyl]sulfanyl}-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid-p-nitrobenzyl ester 
• 161715-24-8 tebipenem 

Relevant articles and documents

Syntheses and pharmacokinetic studies of prodrug esters for the development of oral carbapenem, L-084

We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl- 2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036. Japan Antibiotics Research Association.