1617498-89-1Relevant articles and documents
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors
Smith, Garrick P.,Badolo, Lassina,Chell, Victoria,Chen, I-Jen,Christensen, Kenneth Vielsted,David, Laurent,Daechsel, Justus Alfred,Hentzer, Morten,Herzig, Martin Christian,Mikkelsen, Gitte Kobber?e,Watson, Stephen P.,Williamson, Douglas S.
, p. 4500 - 4505 (2017)
Leucine-rich repeat kinase 2 (LRRK2) has attracted considerable interest as a therapeutic target for the treatment of Parkinson's disease. Compounds derived from a 2-aminopyridine screening hit were optimised using a LRRK2 homology model based on mixed li