1618086-00-2Relevant articles and documents
Copper-catalyzed intermolecular trifluoromethylarylation of alkenes: Mutual activation of arylboronic acid and CF3+ reagent
Wang, Fei,Wang, Dinghai,Mu, Xin,Chen, Pinhong,Liu, Guosheng
supporting information, p. 10202 - 10205 (2014/08/05)
A novel copper-catalyzed intermolecular trifluoromethylarylation of alkenes is developed using less active ether-type Togni's reagent under mild reaction conditions. Various alkenes and diverse arylboronic acids are compatible with these conditions. Preliminary mechanistic studies reveal that a mutual activation process between arylboronic acid and CF3+ reagent is essential. In addition, the reaction might involve a rate-determining transmetalation, and the final aryl C-C bond is derived from reductive elimination of the aryl(alkyl)Cu(III) intermediate.
