16182-36-8

Basic information

• Product Name: Benzenesulfonamide, N-(4,6-dimethyl-2-pyrimidinyl)-4-[[(2-hydroxyphenyl)methylene]amino]-
• CAS NO: 16182-36-8
• Molecular Formula: C19H18N4O3S
• Molecular Weight: 382.443
• Mol File: 16182-36-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(4,6-dimethyl-2-pyrimidinyl)-4-[[(2-hydroxyphenyl)methylene]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(4,6-dimethyl-2-pyrimidinyl)-4-[[(2-hydroxyphenyl)methylene]amino]-(16182-36-8)
• EPA Substance Registry System: Benzenesulfonamide, N-(4,6-dimethyl-2-pyrimidinyl)-4-[[(2-hydroxyphenyl)methylene]amino]-(16182-36-8)

Safety Data

• Hazardous Substances Data: 16182-36-8(Hazardous Substances Data)

Upstream product

• 57-68-1 sulfadimesine 
• 90-02-8 salicylaldehyde 
• 1981-58-4 sodium 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide 

Relevant articles and documents

Selective coordination ability of sulfamethazine Schiff-base ligand towards copper(II): Molecular structures, spectral and SAR study

In the present work, a combined experimental and theoretical study of the N-(4,6-Dimethyl-pyrimidin-2-yl)-4-[(2-hydroxy-benzylidene)amino] benzenesulfonamide ligand (H2L) and its mononuclear and magnetically diluted binuclear CuII complexes has been performed using IR, TG/DTA, magnetic, EPR, and conductivity measurements. Calculated g-tensor values showed best agreement with experimental values from EPR when carried out using the MPW1PW91 functional. Coordination of H2L to a CuII center, regardless of the binding site and Cu:L stoichiometry, leads to a significant decrease in the antibacterial activity compared to the free ligand as well as reference drugs in the case of Staphylococcus aureus. Structural-activity relationship suggests that ELUMO, ΔE, dipole moment, polarizability and electrophilicity index were the most significant descriptors for the correlation with the antibacterial activity.

Schiff bases derived from 4-amino-n-substituted benzenesulfonamide: Synthesis, spectral characterisation and mic evaluation

The present study is aimed to synthesise Schiff bases from sulfathiazole/ sulfamethoxazole/ sulfadimidine with 2-hydroxybenzaldehyde. The synthesized Schiff bases were characterized by analytical data, IR, 1H-NMR, 13C-NMR, UV-Vis spe