16183-76-9Relevant articles and documents
Transition-metal-catalyzed arylation of nitroimidazoles and further transformations of manipulable nitro group
Iaroshenko, Viktor O.,Gevorgyan, Ashot,Mkrtchyan, Satenik,Arakelyan, Knar,Grigoryan, Tatevik,Yedoyan, Julietta,Villinger, Alexander,Langer, Peter
, p. 2103 - 2119 (2015)
Pd- or Ni-catalyzed C-H arylation of 4-nitroimidazole derivatives directed by a manipulable nitro group was developed. The reaction tolerates a wide range of substituted aryl halides and 4-nitroimidazoles. The experiments indicated that the nitro group has influence on regioselectivity of the reaction. In addition, we have shown that the efficiency of the Suzuki-Miyaura cross-coupling reaction of nitroimidazoles is slightly lower in comparison to the direct C-H arylation. The exploration of the chemical potential of the nitro group and a putative reaction mechanism are discussed.