161855-49-8Relevant articles and documents
Synthesis and structure-activity relationships of novel THF 1β- methylcarbapenems
Lin, Yang-I,Bitha, Panayota,Sakya, Subas M.,Strohmeyer, Timothy W.,Li, Zhong,Lee, Ving J.,Lang Jr., Stanley A.,Yang, Youjun,Bhachech, Niraja,Weiss, William J.,Petersen, Peter J.,Jacobus, Nilda V.,Bush, Karen,Testa, Raymond T.,Tally, Francis P.
, p. 1671 - 1676 (1997)
A series of twelve highly active aminomethyl-THF 1β-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice.
