16187-73-8

Basic information

• Product Name: 2-chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}acetamide
• Synonyms: 2-chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}acetamide
• CAS NO: 16187-73-8
• Molecular Weight: 281.662
• Mol File: 16187-73-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}acetamide(16187-73-8)
• EPA Substance Registry System: 2-chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}acetamide(16187-73-8)

Safety Data

• Hazardous Substances Data: 16187-73-8(Hazardous Substances Data)

Upstream product

• 32687-39-1 2-bromo-1-(4-(trifluoromethyl)phenyl)ethanol 
• 339-58-2 2-amino-1-[4-(trifluoromethyl)phenyl]-1-ethanone hydrogen chloride 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 81561-66-2 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine 
• 79-04-9 chloroacetyl chloride 
• 771582-55-9 2-amino-1-[4-(trifluoromethyl)phenyl]ethanone 

Downstream Products

• 7125-73-7 6-[4-(trifluoromethyl)phenyl]morpholin-3-one 
• 62243-72-5 2-[4-(trifluoromethyl)phenyl]morpholine 

Relevant articles and documents

RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE

Provided herein are compounds as RORγ antagonist having Formula (I). The compounds or pharmaceutical composition thereof can be used for regulating Retinoid-related orphan receptor gamma t (RORγt). Also provided herein are methods of preparation of the compounds and composition thereof, and uses thereof in treating or preventing RORγt mediated inflammation or autoimmune diseases in mammals, particularly humans.

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.